Molecular Formula | C22H45N5O17S |
Molar Mass | 683.68 |
Melting Point | 220-230 C |
Boling Point | 981.8°C at 760 mmHg |
Specific Rotation(α) | D22 +74.75° (water) |
Flash Point | 547.6°C |
Water Solubility | Soluble in water at 50mg/ml with warming |
Solubility | H2O: 50mg/mL, clear, colorless |
Vapor Presure | 0mmHg at 25°C |
Appearance | powder |
Color | white to off-white |
Merck | 13,404 |
BRN | 6172633 |
PH | pH(10g/L, 25℃) : 2.0~4.0 |
Storage Condition | Inert atmosphere,2-8°C |
Stability | Hygroscopic |
Use | Anti-Infective Drugs for the treatment of urinary tract infections caused by sensitive bacteria, sepsis, skin infections, bone and joint infections, Pneumonia and lower respiratory tract infections |
In vitro study | Amikacin sulfate has high affinity for 16S rRNA of bacterial 30S ribosome, causing mRNA mistranslation and making bacteria unable to synthesize proteins important for its growth. Amikacin in vitro against Pseudomonas spp., Escherichia Coli, Proteus (indole-positive and indole-negative), Providence spp., Klebsiella-Enterobacter-Serratia spp, acinetobacter spp. (original name Mima-Herellea), and Citrobacter freundii are active. In vitro studies have shown that amikacin sulfate in combination with β-lactam antibiotics acts synergistically on a number of clinically important Gram-negative organisms. In vitro studies have shown that amikacin sulfate in combination with β-lactam antibacterial agents, including moxalactam or piperacillin, acts synergistically on a number of clinically significant Gram-negative organisms. |
In vivo study | In an experimental rabbit model of endocarditis, Amikacin (80 mg/kg I. v.) significantly reduced aortic valve neoplasm Pseudomonas density compared with controls. In addition, once-daily administration of amikacin was more effective than twice-daily administration. Amikacin, administered once, twice, and three times separately at a dose of 50 mg/kg, showed significant activity in a model of avian Mycobacterium tuberculosis complex infection. The addition of Clofazimine significantly increased the activity. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 2 |
RTECS | WK1961200 |
FLUKA BRAND F CODES | 3-10 |
HS Code | 29419000 |
Toxicity | LD50 oral in rabbit: > 3gm/kg |
Raw Materials | Acetone Sulfuric acid |